In today, The combination of lipids and peptides as the materials of the vesicles allows them to both securely carry onto their cargo, while being thermoresponsive, allowing for targeted and controlled drug delivery. While it may seem difficult to create complex 3D structures from different molecular materials while encapsulating a drug, the Japanese researchers were able to develop a method for the vesicles to self-assemble within a specially prepared solution. While similar results have been developed by other teams, the latest development has led to both self-assembled and very strong particles that can survive the challenging environment within the blood stream.
The vesicles can be stored at just about freezing temperature, but when injected they change their structure, opening up and releasing their contents. There’s still work to be done to optimize the process and be able to control the drug release at different temperatures and locations.
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Self-Assembled Hybrid Drug for Safe Passage
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